VIZSLA IDIOPATHIC INFLAMMATORY POLYMYOPATHY
It has been established that the vizsla has a genetic predisposition to VIP and the purpose of the research is to develop a DNA screening test. This work is ongoing
IDIOPATHIC – more
Genetics
RESEARCH
In a peer reviewed article published in 2013 the scientists identified a MHC Class ll haplotype associated with an increased risk of Vizsla Inflammatory Polymyopathy (VIP). A 2019 review and analysis of updated data (c530 samples) confirmed an increased significance for all the previously published associations. In terms of validation this has been very encouraging.
The purpose of the ongoing research is to more precisely identify the genetic mutations associated with Vizsla Inflammatory Polymyopathy (VIP). The hope is to develop a screening test to better inform breeders of the potential risk of producing affected puppies. It is expensive and labour intensive work and so continuing funding is crucial
BREEDING ADVICE
Until it is possible to more clearly define risk the researchers’ advice is to avoid breeding from the first-degree relatives of VIP affected dogs. To reduce homozygosity a low co-efficient of inbreeding should also be aimed for.
The Kennel Club has some excellent guidelines on managing inbreeding and genetic diversity
CAUTION REQUIRED
The Kennel Club advises great caution in the matter of breeding from individuals that have produced offspring with inherited conditions for which no test is available. Immune Mediated disorders are specifically mentioned. This page elaborates
LEGAL CONSIDERATIONS
In the UK breeders will also wish to consider their legal position with regard to the provisions of the Animal Welfare regulations 2016 (Schedule 6)
(5) No dog may be kept for breeding if it can reasonably be expected, on the basis of its genotype, phenotype or state of health that breeding from it could have a detrimental effect on its health or welfare or the health or welfare of its offspring.